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يعتبر فطر الكورديسبس آمن الاستعمال لمعظم الأشخاص، إلا أن هنالك بعض الأعراض الجانبية والتفاعلات الدوائية المحتملة الناتجة عن استعمال فطر الكورديسبس التي يجب الانتباه لها، والتي تتضمن ما يلي:S